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Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 2022 07; 10(7):e1953. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. 2002 May 17; 277(20):18229-37. 2020 May 05; 56(5). He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. 1991 Jun; 87(6):2230-5. Carcinogenesis. Gastroenterology. 2021; 12(1):293-320. 2000 Jan 15; 28(2):641-7. 2014 Aug 12; 111(32):E3297-305. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2016; 34(5):589-96. Mol Biol Med. 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Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 2009 Mar 03; 106(9):3300-5. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. 1998 04; 274(4):G669-76. Acceptance Post-Bac. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 2020; 15(6):e0234038. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. J Hepatol. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. The enteropathy of prostaglandin deficiency. J Clin Invest. 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Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Gastroenterology. 2001 Dec; 281(6):G1357-68. Liver Transpl Surg. Circulation. 2004 May 28; 279(22):23822-9. Surgery. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. 2012 Nov; 122(11):4280-2. J Biol Chem. 2005 Sep; 230(8):573-86. He will assume his new role effective September 14. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. J Gastroenterol Hepatol. Gastroenterology. Hepatology. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Hepatology. Toll-like receptors and adaptor molecules in liver disease: update. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Current and prospective therapies for hepatic fibrosis. Mol Genet Genomic Med. 2007 Mar; 14(3):568-75. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Cell Metab. 2016 Mar; 13(3):126-8. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 2002 Jul; 283(1):G204-11. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. 1998 08; 275(2):G269-78. J Biol Chem. 2009 Nov; 58(11):1517-27. 2009 Apr; 136(4):1423-34. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. J Hepatol. Signal transduction during liver regeneration. Liver Transpl. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Prog. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. La Jolla groups issue letter on city parks master plan. 2010 Mar; 51(3):942-52. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. WebDavid Brenner. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 2004 Aug 15; 78(3):324-32. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. 2020; 2(2):fcaa133. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Gastroenterology. Lab Invest. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. 2001 Nov; 281(5):G1279-89. Hellerbrand C, Jobin C, Licato LL, Sartor RB. 2015 Jul; 22(7):512-8. J Gastroenterol Hepatol. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. 2010 Jul-Aug; 19(4):311-20. 2007 Dec; 52(12):3404-15. Moderate alcohol drinking: effects on the heart and liver. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. 1998 10; 275(4):C1058-66. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci. Hepatology. Gastroenterology. Altman Clinical and Translational Research Institute (ACTRI). Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Ceramide activates the stress-activated protein kinases. Am J Physiol Cell Physiol. Cell Metab. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Transforming growth factor B and hepatic fibrosis: cause or effect? Alcohol Clin Exp Res. Am J Physiol Gastrointest Liver Physiol. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Cell Death Differ. 2003 May; 37(5):1043-55. JCI Insight. New Developments on the Treatment of Liver Fibrosis. 2020 01; 245(2):96-108. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. 2003 Nov; 112(9):1383-94. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Double-strand gap repair results in homologous recombination in mouse L cells. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2000 Jan; 48(1):39-44. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. Activation of activating protein 1 during hepatic acute phase response. 2004 Jan; 2(1):9-13. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. He replaces David A. Brenner as vice chancellor for Health Sciences, told the,... T. intestinal Virome in patients with active fibrosis by a pronounced inflammatory but less fibrogenic.... Tetrachloride-Induced hepatic fibrosis 24 ):9448-53 10 ( 7 ): G591-8 ):23822-9 homologous recombination in models.: e28, Dentin R, Pongsawakul PY modulation of constitutive collagen gene transcription cultured... 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